Evaluation of Xpert MTB/RIF Ultra Assay for Diagnosis of Childhood Tuberculosis: a Multicenter Accuracy Study-Reference-Cited by-同舟云学术

Evaluation of Xpert MTB/RIF Ultra Assay for Diagnosis of Childhood Tuberculosis: a Multicenter Accuracy Study

Published:2020-08-24 Issue:9 Volume:58 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Sun Lin¹,Zhu Yu²,Fang Min³,Shi Yan³,Peng Xiaoshan²,Liao Qiong²,Wang Xingyun¹,Quan Shuting¹,Wang Yacui¹,Duan Li³,Shi Xiaomei³,Zhao Zhipeng¹,Chen Lanqin¹,Xu Yongsheng⁴,Zhang Tongqiang⁴,Cui Xiaojian⁴,Wan Chaomin²,Shen Adong¹^ORCID

Affiliation:

1. Beijing Children’s Hospital, Capital Medical University, Beijing, China

2. West China Second Hospital, Sichuan University, Chengdu, Sichuan, China

3. No. 1 People’s Hospital of Liangshan Yizu Autonomous Prefecture, Liangshan, Sichuan, China

4. Tianjin Children’s Hospital, Tianjin, China

Abstract

A multicenter study was performed to evaluate the value of testing gastric aspirate (GA) with Xpert MTB/RIF Ultra assay (Ultra) for childhood tuberculosis (TB) detection in China. In total, 129 children with active TB and 173 children without TB were enrolled. The sensitivity of Ultra in bacteriologically confirmed TB and probable TB cases was 87.5% (42/48) and 44.4% (36/81), respectively. The specificity of Ultra was high (99.4%, 172/173). When Ultra, culture, and acid-fast bacilli outcomes were integrated as a composite reference standard, the percentage of children with definite TB increased from 37.

Funder

MOST | National Science and Technology Planning Project

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00702-20

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