Strain-Dependent Variation in Mycobacterium bovis BCG-Induced Human T-Cell Activation and Gamma Interferon Production In Vitro-Reference-Cited by-同舟云学术

Strain-Dependent Variation in Mycobacterium bovis BCG-Induced Human T-Cell Activation and Gamma Interferon Production In Vitro

Published:2007-06 Issue:6 Volume:75 Page:3197-3201
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Aguirre-Blanco Ana M.¹,Lukey Pauline T.²,Cliff Jacqueline M.¹,Dockrell Hazel M.¹

Affiliation:

1. Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

2. GlaxoSmithKline R&D, Stevenage, United Kingdom

Abstract

ABSTRACT Three commonly used Mycobacterium bovis BCG vaccine strains elicited different magnitudes of T-cell activation and gamma interferon production in vitro in healthy BCG-vaccinated individuals. Glaxo 1077 exhibited the greatest stimulatory capacity, followed by Pasteur 1173 and then Danish 1331. These differences may affect in vitro stimulation and vaccination-induced immunogenicity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.01611-06

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