Pharmacokinetics of Intracameral Voriconazole Injection

Author:

Shen Ying-Cheng12,Wang Mei-Yen3,Wang Chun-Yuan14,Tsai Tsun-Chung3,Tsai Hin-Yeung14,Lee Hsin-Nung1,Wei Li-Chen12

Affiliation:

1. Department of Ophthalmology, Taichung Veterans General Hospital, Taiwan, Republic of China

2. Overseas Chinese Institute of Technology, Taichung, Taiwan, Republic of China

3. Department of Food Science, Tunghai University, Taiwan, Republic of China

4. Hung Kuang University, Taiwan, Republic of China

Abstract

ABSTRACT Elimination of voriconazole after intracameral injection exhibited an exponential decay with a half-life of 22 min. Voriconazole levels in the vitreous humor were below the detectable limit. The aqueous concentrations achieved with a 25-μg dose during the first 2 h were greater than the previously reported MICs of organisms most involved in fungal endophthalmitis. A rapid decline in intracameral concentration suggests that frequent supplementation of intracameral voriconazole may be required in clinical settings.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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