Yersinia pestis Δ <i>ail</i> Mutants Are Not Susceptible to Human Complement Bactericidal Activity in the Flea-Reference-Cited by-同舟云学术

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Yersinia pestis Δ ail Mutants Are Not Susceptible to Human Complement Bactericidal Activity in the Flea

Published:2023-02-28 Issue:2 Volume:89 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Kolodziejek Anna M.¹,Bearden Scott W.²,Maes Sarah²,Montenieri John M.²,Gage Kenneth L.²,Hovde Carolyn J.¹,Minnich Scott A.¹^ORCID

Affiliation:

1. Department of Animal, Veterinary and Food Science, University of Idaho, Moscow, Idaho, USA

2. Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA

Abstract

This work contributes to our understanding of how highly virulent Y. pestis evolved from its innocuous enteric predecessor. Among identified virulence factors is the attachment invasion locus protein, Ail, that is required to protect Y. pestis from serum complement in all mammals tested except mice.

Funder

HHS | National Institutes of Health

U.S. Department of Agriculture

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.01244-22

Reference71 articles.

1. Microevolution and history of the plague bacillus, Yersinia pestis

2. Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis

3. Early Divergent Strains of Yersinia pestis in Eurasia 5,000 Years Ago

4. The Stone Age Plague and Its Persistence in Eurasia

5. Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague

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