Evaluation of Methods To Identify the Klebsiella pneumoniae Carbapenemase in Enterobacteriaceae-Reference-Cited by-同舟云学术

Evaluation of Methods To Identify the Klebsiella pneumoniae Carbapenemase in Enterobacteriaceae

Published:2007-08 Issue:8 Volume:45 Page:2723-2725
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Anderson K. F.¹,Lonsway D. R.¹,Rasheed J. K.¹,Biddle J.¹,Jensen B.¹,McDougal L. K.¹,Carey R. B.¹,Thompson A.¹,Stocker S.¹,Limbago B.¹,Patel J. B.¹

Affiliation:

1. Centers for Disease Control and Prevention, Division of Healthcare Quality Promotion, Atlanta, Georgia

Abstract

ABSTRACT The Klebsiella pneumoniae carbapenem (KPC) β-lactamase occurs in Enterobacteriaceae and can confer resistance to all β-lactam agents including carbapenems. The enzyme may confer low-level carbapenem resistance, and the failure of susceptibility methods to identify this resistance has been reported. Automated and nonautomated methods for carbapenem susceptibility were evaluated for identification of KPC-mediated resistance. Ertapenem was a more sensitive indicator of KPC resistance than meropenem and imipenem independently of the method used. Carbapenemase production could be confirmed with the modified Hodge test.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00015-07

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