Phenethyl Alcohol I. Effect on Macromolecular Synthesis of Escherichia coli

Author:

Rosenkranz Herbert S.1,Carr Howard S.1,Rose Harry M.1

Affiliation:

1. Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York

Abstract

Rosenkranz, Herbert S. (Columbia University, New York, N.Y.), Howard S. Carr, and Harry M. Rose . Phenethyl alcohol. I. Effect on macromolecular synthesis of Escherichia coli . J. Bacteriol. 89: 1354–1369. 1965.—An investigation of the mode of action of phenethyl alcohol produced the following results. Phenethyl alcohol had no effect on the physicochemical properties of isolated deoxyribonucleic acid (DNA). The DNA isolated from phenethyl alcohol-treated bacteria had physicochemical properties identical with those of DNA isolated from normal cells. The metabolic functions most sensitive to the inhibitory action of phenethyl alcohol appeared to be the process of enzyme induction and, possibly, the synthesis of messenger ribonucleic acid. Phenethyl alcohol did not affect the polyuridylic acid-mediated synthesis of polyphenylalanine in a cell-free amino acid-incorporating system.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference67 articles.

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3. BENDICH A. E. BORENFREUND G. C. KORNGOLD M. KRIM AND M. E. BALIS. 1964. Amino acids or small peptides as punctuation in the genetic code of DNA p. 214-237. In A. Baselli fed.] Acidi nucleici e loro funzione biologica. Tipografia Succession Fusi Pavia.

4. BENDICH A. AND H. S. ROSENKRANZ. 1963. Some thoughts on the double-stranded model of deoxyribonucleic acid p. 219-230. In J. N. Davidson and W. E. Cohn [ed.] Progress in nucleic acid research vol. 1. Academic Press Inc. New York.

5. Selective and reversible inhibition of the synthesis of bacterial deoxyribonucleic acid by phenethyl alcohol;BERRAH G.;J. Bacteriol.,1962

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