Author:
Shrestha Basudha,Tada Tatsuya,Miyoshi-Akiyama Tohru,Shimada Kayo,Ohara Hiroshi,Kirikae Teruo,Pokhrel Bharat M.
Abstract
ABSTRACTA novel New Delhi metallo-β-lactamase, NDM-13, was identified in a carbapenem-resistantEscherichia coliclinical isolate obtained from the urine of a patient in Nepal. The enzymatic activity of NDM-13 against β-lactams was similar to that of NDM-1. However, NDM-13 displayed significantly higherkcat/Kmratios for cefotaxime. The genetic environment ofblaNDM-13was determined to betnpA-IS30-blaNDM-13-bleMBL-trpF-dsbC-cutA-groES-groL, withblaNDM-13located within the chromosome.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
27 articles.
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