The Vi Capsular Polysaccharide of Salmonella Typhi Promotes Macrophage Phagocytosis by Binding the Human C-Type Lectin DC-SIGN

Author:

Zhang Lillian F.1,Lepenies Bernd2,Nakamae Sayuri3,Young Briana M.1,Santos Renato L.1,Raffatellu Manuela45ORCID,Cobb Brian A.6,Hiyoshi Hirotaka17,Bäumler Andreas J.1ORCID

Affiliation:

1. Department of Medical Microbiology and Immunology, University of California at Davis, Davis, California, USA

2. Institute for Immunology & Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hanover, Germany

3. Department of Immune Regulation, Shionogi Global Infectious Diseases Division, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan

4. Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, California, USA

5. Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla, California, USA

6. Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA

7. Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan

Abstract

Salmonella entericasubspeciesentericaserovar Typhi is the causative agent of typhoid fever. The recent emergence ofS.Typhi strains which are resistant to antibiotic therapy highlights the importance of vaccination in managing typhoid fever.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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