Activity of Ivermectin and Its Metabolites against Asexual Blood Stage Plasmodium falciparum and Its Interactions with Antimalarial Drugs

Author:

Yipsirimetee Achaporn1ORCID,Tipthara Phornpimon2,Hanboonkunupakarn Borimas12,Tripura Rupam23,Lek Dysoley4,Kümpornsin Krittikorn56,Lee Marcus C. S.5ORCID,Sattabongkot Jetsumon7,Dondorp Arjen M.23,White Nicholas J.23,Kobylinski Kevin C.28,Tarning Joel23ORCID,Chotivanich Kesinee12ORCID

Affiliation:

1. Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

2. Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

3. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom

4. National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia

5. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom

6. Calibr, Division of the Scripps Research Institute, La Jolla, California, USA

7. Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

8. Department of Entomology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand

Abstract

Ivermectin is an endectocide used widely to treat a variety of internal and external parasites. Field trials of ivermectin mass drug administration for malaria transmission control have demonstrated a reduction of Anopheles mosquito survival and human malaria incidence.

Funder

Royal Golden Jubilee (RGJ) Ph.D. Programme

Wellcome Trust

Bill and Melinda Gates Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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