SYSTEMIC MORPHOFUNCTIONAL ASSESSMENT OF THE STATE OF CARDIOMYOCYTES OF EXPERIMENTAL ANIMALS AFTER PROLONGED PHYSICAL LOAD WITH SUBSEQUENT REST

Abstract

The aim of the research is to find out the nature of the impact of a combination of extreme physical activity and different duration of post-exercise rest on the function of myocardial contractility in experimental animals. To achieve this goal, the following tasks were set: to carry out a comparative analysis of the patterns of ultrastructural organization of cardiac muscle cells in two groups of animals: a) normal healthy animals living with normal daily physical activity, and b) animals adapted to prolonged maximum physical activity; to assess the strength of myocardial contractility using a multivariate systemic quantitative morphological analysis based on the methodology of Quantitative Functional Morphology (QFM); to check the adequacy and evaluate the accuracy of the QFM method for measuring cardiomyocyte myocardial contractility by conducting simultaneous and parallel measurements of the force of myocardial contractility using a direct measurement method by micromechanography; to carry out a comparative correlation analysis of the factors that may cause the detected scatter in the data on myocardial contractility in swimming rats. Taking into account the characteristics of the body of athletes, it is advisable to choose for each athlete an individual mode of the duration and strength of loads, as well as the duration of post-load rest based on objective data, especially before the upcoming competitions.