Affiliation:
1. NİĞDE ÖMER HALİSDEMİR ÜNİVERSİTESİ, SÜREKLİ EĞİTİM UYGULAMA VE ARAŞTIRMA MERKEZİ
2. AYDIN ADNAN MENDERES ÜNİVERSİTESİ, TIP FAKÜLTESİ
Abstract
Background: The present study aims to investigate whether proinflammatory marker ratios in whole blood differ in these two dementia diseases.
Materials and Methods:
This study will involve Alzheimer's disease (AD) and vascular dementia (VaD) patients who were treated as outpatients in the outpatient clinic and inpatients in the ward of the Neurology Department of Adnan Menderes University Hospital. The patients’ diagnoses will be scanned in the hospital information system. The admission blood results of patients who presented between January 2018 and September 2020 will be included, and the patients’ hemogram results will be scanned retrospectively. Neutrophil/lymphocyte, monocyte/lymphocyte, and platelet/lymphocyte ratios in the hemogram results will be calculated and recorded.
Results:
In the AD-VaD comparison of the patients participating in the study, a significant difference was identified between the variability of platelet/lymphocyte (PLR) and NLRs (NLR) (p
Publisher
Acil Tip Uzmanlari Dernegi
Reference23 articles.
1. 1.Braak ve Braak, 1991; de Toledo-Morrell, Goncharova, Dickerson, Wilson ve Bennett, 2000
2. 2.Askarova S, Yang X, Lee J. Impacts of MembraneBiophysics in Alzheimer’sDisease: FromAmyloidPrecursor Protein Processingto Aβ Peptide-InducedMembraneChanges. International Journal of Alzheimer’sDisease, 2011;10 (4061):1-12
3. 3. Scheff SW, PriceDA, Schmitt FA, Mufson EJ. Hippocampalsynapticloss in earlyAlzheimer'sdiseaseandmildcognitiveimpairment. NeurobiolAging, 2006;27 (10):1372-1384.
4. 4. Hebert LE, Weuve J, Scherr PA, Evans DA. Alzheimer disease in the United States (2010-2050) estimatedusingthe 2010 census. Neurology. 2013;80(19):1778-83
5. 5. . Frances A, Pincus HA, First MB. Diagnosticand Statistical Manual of MentalDisordersFourth Edition (DSM IV). Washington: AmericanPsychiatricAssociation, 1994; p: 133– 56