One hundred years after the discovery of insulin and glucagon: the history of tumors and hyperplasias that hypersecrete these hormones

Author:

de Herder Wouter W1ORCID,Klöppel Günter2ORCID

Affiliation:

1. Department of Internal Medicine, Sector of Endocrinology, Erasmus MC & Erasmus MC Cancer Institute, ENETS Center of Excellence, Rotterdam, the Netherlands

2. Department of Pathology, Technical University Munich, Munich, Germany

Abstract

One century ago, in 1922, Frederick G Banting, Charles H Best, James B Collip and John J R Macleod first published their experiments resulting in the isolation of a hypoglycemic factor, named insulin, from a solution extract from a dog’s pancreas. One year later, in 1923, a hyperglycemic factor named glucagon was isolated by Charles P Kimball and John R Murlin. In the following years, it could be demonstrated that pancreatic islet alpha- and beta-cell neoplasms and hyperplasias could inappropriately secrete excessive amounts of these two hormones. This review is a sequel to the discovery of insulin and glucagon and introduces the history of this fascinating group of neuroendocrine neoplasms and hyperplasias of the pancreas.

Publisher

Bioscientifica

Subject

Cancer Research,Endocrinology,Oncology,Endocrinology, Diabetes and Metabolism

Reference136 articles.

1. Emerging therapies for malignant insulinomas and glucagonomas;Alexandraki,2023

2. Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndrome;Anlauf,2006

3. Insulinomatosis: a multicentric insulinoma disease that frequently causes early recurrent hyperinsulinemic hypoglycemia;Anlauf,2009

4. Further clinical experience with insulin (pancreatic extracts) in the treatment of diabetes mellitus;Banting,1923

5. The internal secretion of the pancreas;Banting,1922

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1. Glucagon and insulin: 100 years young;Endocrine-Related Cancer;2024-05-01

2. Case report: Insulinomatosis: description of four sporadic cases and review of the literature;Frontiers in Endocrinology;2024-01-09

3. Approach to the Patient: Insulinoma;The Journal of Clinical Endocrinology & Metabolism;2023-10-31

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