SEX HORMONE BINDING GLOBULIN BINDING CAPACITY, TESTOSTERONE, 5α-DIHYDROTESTOSTERONE, OESTRADIOL AND PROLACTIN IN PLASMA OF PATIENTS WITH PROSTATIC CARCINOMA UNDER VARIOUS TYPES OF HORMONAL TREATMENT

Abstract

ABSTRACT Sex hormone binding globulin (SHBG) binding capacity, the concentrations of testosterone (T), of 5α-dihydrotestosterone (DHT), of oestradiol-17β (Oe2), of oestrone (Oe1), of prolactin (hPr) and the percentual specific binding of T to SHBG (% TB) were measured in plasma of patients suffering from prostatic carcinoma and of a control group of similar age. No significant differences in any of the investigated parameters were found between the control group and the carcinoma patients before treatment although 15 % of the latter showed distinctly elevated hPr values. Treatment of carcinoma patients with 1) Antiandrogen (cyproterone acetate, Androcur®) resulted in a significant decrease of T, Oe2 and SHBG. The DHT/T-ratio increased. n = 5. 2) Orchidectomy caused an even more pronounced fall in T, DHT, Oe1 and Oe2 blood levels. SHBG was not altered. DHT/T-ratio increased. n = 32. 3) Cyproterone acetate after orchidectomy led to elevated hPr values. n = 5. 4) Oestrogen (diethylstilboestrol-diphosphate, Honvan®) after orchidectomy increased SHBG and hPr. n = 6. 5) Corticosteroid (Prednisone, Decortin®) after orchidectomy decreased T and SHBG below the levels found after orchidectomy alone, n = 5. 6) Diureticum (Mefruside, Baycaron®) (n = 5) or 7) a placebo (n = 7) did not alter any of the parameters measured. 8) Treatment with HCG (Primogonyl®) of patients suffering from oligozoospermia resulted in a significant increase of T, DHT and Oe2. SHBG was not altered. DHT/T-ratio decreased, n = 7.