Liver Histological Improvement After Administration of High-Dose Vitamin C in Guinea Pig with Nonalcoholic Steatohepatitis
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Published:2018-12-01
Issue:5-6
Volume:88
Page:263-269
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ISSN:0300-9831
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Container-title:International Journal for Vitamin and Nutrition Research
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language:en
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Short-container-title:International Journal for Vitamin and Nutrition Research
Author:
Park Seong-Hoon1, Han A Lum2, Kim Na-Hyung3, Shin Sae-Ron2
Affiliation:
1. Departments of Radiology Medicine, Medical Hospital, Wonkwang University, Iksan, Chonbuk, Republic of Korea 2. Departments of Family Medicine, Medical hospital, Wonkwang University, Iksan, Chonbuk, Republic of Korea 3. Departments of Oriental Pharmacy, Wonkwang University, Iksan, Chonbuk, Republic of Korea
Abstract
Abstract. Background: Vitamin C is a strong antioxidant, and the health effects of vitamin C megadoses have not been validated despite the apparent health benefits. Therefore, the present study sought to confirm the effects of vitamin C megadoses. Materials and Methods : Four groups of six guinea pigs were used. Each group was fed one of the following diets for three weeks: normal diet, methionine choline-deficient diet, methionine choline-deficient diet + vitamin C megadose (MCD + vit C 2.5 g/kg/day), and methionine-choline deficient diet + ursodeoxycholic acid (MCD + UDCA 30 mg/kg/day). The MCD diet was given to induce nonalcoholic steatohepatitis, and UDCA was used to treat nonalcoholic steatohepatitis. Three weeks after initial diet administration, the results of biochemical tests and liver biopsy were compared between the groups. Results: The cytoplasm state was similar in the MCD + vit C and MCD + UDCA groups, exhibiting clearing of the cytoplasm and ballooning degeneration. However, macrovesicular steatosis was not observed in the MCD + vit C group. Aspartate transaminase and alanine transaminase were elevated significantly following vitamin C administration. Conclusions: The present study confirmed that alone vitamin C megadoses are potential remedies for nonalcoholic steatohepatitis, based on the liver biopsy results of guinea pigs that were unable to synthesize vitamin C.
Publisher
Hogrefe Publishing Group
Subject
Nutrition and Dietetics,General Medicine,Endocrinology, Diabetes and Metabolism,Medicine (miscellaneous)
Reference34 articles.
1. Bellentani, S., Scaglioni, F., Marino, M. and Bedogni, G. (2010) Epidemiology of non-alcoholic fatty liver disease. Dig. Dis. 28, 155–61. 2. Ludwig, J., Viggiano, T.R., McGill, D.B. and Oh, B.J. (1980) Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo. Clin. Proc. 55, 434–8. 3. Brunt, E.M. (2001) Nonalcoholic steatohepatitis: definition and pathology. Semin. Liver. Dis. 21, 3–16. 4. Matteoni, C.A., Younossi, Z.M., Gramlich, T., Boparai, N., Liu, Y.C. and McCullough, A.J. (1999) Nonalcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 116, 1413–9. 5. Powell, E.E., Cooksley, W.G., Hanson, R., Searle, J., Halliday, J.W. and Powell, L.W. (1990) The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 11, 74–80.
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