Serum carotenoid levels are positively associated with DNA methylation of thioredoxin-interacting protein

Author:

Maeda Keisuke1ORCID,Yamada Hiroya2,Munetsuna Eiji3,Fujii Ryosuke45ORCID,Yamazaki Mirai6ORCID,Ando Yoshitaka7ORCID,Mizuno Genki8,Tsuboi Yoshiki4ORCID,Ishikawa Hiroaki7,Ohashi Koji7,Hashimoto Shuji2,Hamajima Nobuyuki9,Suzuki Koji4

Affiliation:

1. Department of Clinical Physiology, Fujita Health University School of Medical Sciences, Toyoake, Japan

2. Department of Hygiene, Fujita Health University School of Medicine, Toyoake, Japan

3. Department of Biochemistry, Fujita Health University School of Medicine, Toyoake, Japan

4. Department of Preventive Medical Sciences, Fujita Health University School of Medical Sciences, Toyoake, Japan

5. Institute for Biomedicine (affiliated to the University of Lübeck), Eurac Research, Bolzano/Bozen, Italy

6. Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Takamatsu, Japan

7. Department of Informative Clinical Medicine, Fujita Health University School of Medical Sciences, Toyoake, Japan

8. Department of Medical Technology, School of Health Sciences, Tokyo University of Technology, Tokyo, Japan

9. Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya, Japan

Abstract

Abstract: Background: Carotenoids have been reported to exert protective effects against age-related diseases via changes in DNA methylation. Although lower thioredoxin-interacting protein (TXNIP) DNA methylation is associated with age-related diseases, only a few studies have investigated the factors influencing TXNIP DNA methylation. Carotenoids may be a factor linking TXNIP to specific pathophysiological functions. The aim of this study was to examine whether serum carotenoid levels are associated with TXNIP DNA methylation levels. Methods: We conducted a cross-sectional study using 376 health examination participants (169 men). DNA methylation levels were determined using a pyrosequencing assay. Serum carotenoid levels were determined by high-performance liquid chromatography. Multivariable regression analyses were performed to examine the associations between TXNIP DNA methylation levels and serum carotenoid levels with adjustment for age, BMI, HbA1c, CRP, smoking habits, alcohol consumption, exercise habits, and percentage of neutrophils. Results: Multiple linear regression analyses showed that TXNIP DNA methylation levels were positively associated with serum levels of zeaxanthin/lutein ( β [95%CI]: 1.935 [0.184, 3.685]), β-cryptoxanthin (1.447 [0.324, 2.570]), α-carotene (1.061 [0.044, 2.077]), β-carotene (1.272 [0.319, 2.226]), total carotenes (1.255 [0.040, 2.469]), total xanthophylls (2.133 [0.315, 3.951]), provitamin A (1.460 [0.402, 2.519]), and total carotenoids (1.972 [0.261, 3.683]) in men (all p<0.05). Of these, provitamin A showed the stronger association (standardized β=0.216). No significant association of TXNIP DNA methylation and serum carotenoid was observed in women. Conclusions: The findings of this study suggest that carotenoid intake may protect against age-related diseases by altering TXNIP DNA methylation status in men.

Publisher

Hogrefe Publishing Group

Subject

Nutrition and Dietetics,General Medicine,Endocrinology, Diabetes and Metabolism,Medicine (miscellaneous)

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3