Somatotype and microbiome: trends and correlations in liver cirrhosis

Abstract

Introduction. Characteristic changes against the background of liver cirrhosis are violations of the composition and number of representatives of the intestinal microbiota (intestinal dysbiosis) and excessive bacterial growth in the small intestine. The aim is to identify a correlation between the somatotype of a patient with liver cirrhosis and changes in the composition of the intestinal microbiota. Material and methods. The study included 46 patients diagnosed with liver cirrhosis of various etiologies. The somatotype of the patients was determined using a bioimpedance analyzer of body composition (ABC-01 "Medass"). The intestinal microbiota was analyzed once by 16s rRNA sequencing. The processing of the received data was carried out using the program “Statistica". Results. Among 46 patients diagnosed with liver cirrhosis, the majority (26 patients) had a mesoendomorphic somatotype, 14 patients were representatives of endomesomorphs. The predominance of representatives of the genera Streptococcus (p-value = 0.02), Campylobacter (p-value = 0.049) and Holdemanella (p-value = 0.048) was statistically significant in the group of endomesomorphs, while bacteria from the genera Klebsiella (p-value = 0.01) and Gammaproteobacteria (p-value = 0.048) prevailed in the group of mesoendomorphs.value = 0.02). Taxa of the intestinal microbiota of Pyramidobacter were expressed in patients with endomorphic somatotype (p-value = 0.016). Conclusions. Different somatotypes of patients with liver cirrhosis are associated with certain taxa of the intestinal microbiota, which prevail over other families of bacteria.