Application of CT perfusion imaging in NSCLC and its correlation with angiogenesis and lymph node metastasis

Y.-S. Chen, W.-H. Lin, A.-L. Zhang, Y. Lin

Department of Radiology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, P.R. China. 13960169668@126.com

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• Radiology

OBJECTIVE: To investigate the application of computed tomography (CT) perfusion imaging in non-small cell lung cancer (NSCLC) and its correlation with angiogenesis and lymph node metastasis.

PATIENTS AND METHODS: A total of 100 patients with NSCLC were selected as the study subjects. They were admitted to our hospital from January 2013 to January 2018. All patients were examined by CT perfusion imaging after admission. The differences and correlations of CT perfusion imaging parameters between patients with different angiogenesis and pathological conditions were analyzed.

RESULTS: There was no significant difference in CT perfusion imaging parameters between patients with different tissue types. Blood flow (BF) in patients with lymph node metastasis was significantly higher than that in patients with non-lymph node metastasis. Blood value (BV) and peak enhancement index (PEI) in patients with lymph node metastasis were lower than those in patients with non-lymph node metastasis. There was no significant difference in mean transit time (MTT) between patients with different lymph node metastasis. The BF of stage I-II patients was significantly higher than that of stage III-IV patients, and there was no significant difference in other indexes (p < 0.05). There was significant difference in micro-vessel density (MVD) between patients with different pathological tissues and lymphatic metastasis (p < 0.05). There was no significant difference in MVD between patients with different TNM stages (p > 0.05). Lymph node metastasis and MVD are negatively correlated with CT perfusion imaging indices BF, BV and PEI, respectively.

CONCLUSIONS: CT perfusion imaging technology can reflect the formation of pulmonary capillaries and the ability of metastasis and dissemination of tumors to a certain extent.

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