Effect of Gel from Erythrina Subumbrans and Plectranthus Amboinicus Leaf Extracts as Anti-Inflammatory Agent in Male Balb/c Mice

Abstract

Background: Various types of nutritious plants owned by Indonesia can be used as traditional medicine by the community because they are considered more economical and cause fewer side effects than chemical drugs. For example, the dadap plant (Erythrina subumbrans) and the cumin plant (Plectranthus amboinicus) which have potential as anti-inflammatory drugs. Dadap leaves contain active ingredients, such as alkaloids, flavonoids, and tannins. Meanwhile, cumin leaves contain saponins, flavonoids, polyvenols, and essential oils. Flavonoids work by inhibiting the action of COX-2 which causes inflammation. Objective: This study aimed to determine the effectiveness of the extract gel of dadap leaves and cumin leaves as anti-inflammatory in male Balb/c mice. Methods: The research was carried out through the stages of making extracts, making gel formulas, and induction of inflammation in male mice by use caragens. The data analysis method used was the ANOVA test which was obtained by observing the tumor, calor, rubor, and dolor of male mice. Conclusion: Dadap leaves and cumin leaves can be used as anti-inflammatory gels on the extremities. The three gel formulations of dadap leaves and cumin leaves can relieve inflammation. Results: From the test on mice, the most effective gel formulation was the formulation of 7.5% dadap leaf extract and 17.5% cumin leaf extract.