Development of Blumea lacera Gel Targeting Skin Disease-Reference-Cited by-同舟云学术

Development of Blumea lacera Gel Targeting Skin Disease

Published:2024-07-01 Issue:2 Volume:21 Page:547-553
ISSN:2456-2602
Container-title:Biosciences Biotechnology Research Asia
language:en
Short-container-title:Biosci., Biotech. Res. Asia

Author:

Jagdale Swati Changdeo¹^ORCID,Gijare Arya Jayant¹^ORCID,Pardeshi Kunal Jitendra¹^ORCID,Mandot Aryan Mangesh¹^ORCID

Affiliation:

1. School of Health Sciences and Technology, Department of Pharmaceutical Sciences, Dr. Vishwanath Karad MIT World Peace University, MIT Campus, Kothrud, Pune, MH, India.

Abstract

ABSTRACT: Tribal people utilize Blumea lacera leaves for the treatment of skin injury. This plant has antibacterial and therapeutic qualities, according to ayurveda. Present study was aimed to formulate and evaluate an antimicrobial gel using Blumea lacera leaf extract for the treatment of skin diseases. Chemical identification tests and phytochemical screening were carried out to ascertain the presence of bio-active compounds. The extract efficacy was initially assessed through the agar plate method and diffusion test. The chemical identification tests revealed presence of alkaloids, flavonoids, tannins, and terpenoids in the leaf extract. It also revealed inhibitory effects against various microbial strains. Molecular docking studies matched with the antimicrobial compounds in docking to prove its activity. The docking scores of the nominated phytoconstituents (PubChem ID – 1548943, 6989) showed a higher interaction score. Polymer carbopol 940 in 1.12% exhibited good gelling property to the formulated gel of leaf extract powder. It has shown sustained effect for 8 hours. This comprehensive analysis enhances our understanding for the antimicrobial potential of the formulated gel, paving the way for future developments in plant-based antimicrobial agents targeting skin diseases.

Publisher

Oriental Scientific Publishing Company

Reference22 articles.

1. 1. Sahoo N., Manchikanti P., Dey, S. Herbal drugs: standards and regulation. Fitoterapia . 2014; 96: 1-10.

2. 2. Mallaiah S.H., Akram M., Kadir M.A., Majid A. Blumea lacera (Burm.f.) DC: an overview. Pharm. Sci. Inno. 2018; 7(3): 91-97.

3. 3. Nair A., Agarwal R., Rana A.C. Blumea lacera (Burm. f.) DC: ethnomedicinal uses, chemical constituents and pharmacological properties – A review. Pacific J. Trop. Biomed. 2016; 6(7): 558-564.

4. 4. Aranico E.C., Torres M.F., Flores L.S. Antibacterial activity of Blumea laera DC (Sambong) against selected bacterial strains. Pharm. Sci. Res. 2016; 8(11): 1199-1201.

5. 5. Saini V., Goyal P. K., Chaudhary G. Evaluation of antioxidant, anti-inflammatory and anti-nociceptive activities of Blumea lacera. Oriental Pharm. Expet. Med. 2014; 14(3): 227-233.