The role of microbiome in uveitis-Reference-Cited by-同舟云学术

The role of microbiome in uveitis

Published:2023-12-25 Issue: Volume: Page:1001-1013
ISSN:2692-3106
Container-title:Exploration of Medicine
language:
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Author:

Amin Hind¹,Shoughy Samir²^ORCID

Affiliation:

1. Department of Ophthalmology, Faculty of Medicine, Alexandria University, Alexandria 5372066, Egypt

2. Doctor Samir Eye Clinic, Alexandria 5432013, Egypt; Kafr Elsheikh Ophthalmology Hospital, Kafr El Sheikh 6860506, Egypt

Abstract

The gut microbiota comprises a complex bacterial community that resides in the intestine. Imbalances in the gut microbiota can disrupt immune homeostasis, triggering autoimmune diseases including non-infectious uveitis. Despite recent advances, the underlying mechanisms linking the microbiome and uveitis are not fully understood. This review offers a comprehensive analysis of the literature addressing microbiome’s relationship with ocular inflammation. Additionally, it explores the potential of modulating the gut microbiota as a novel therapeutic target. A literature search of published articles related to the role of ocular microbiome in non-infectious uveitis in PubMed and Scopus databases was conducted. The following keywords were used: microbiome, uveitis, and immune-mediate diseases.

Publisher

Open Exploration Publishing

Subject

Molecular Medicine

Reference75 articles.

1. Nakamura YK, Metea C, Karstens L, Asquith M, Gruner H, Moscibrocki C, et al. Gut microbial alterations associated with protection from autoimmune uveitis. Invest Ophthalmol Vis Sci. 2016;57:3747–58.

2. Shivaji S. We are not alone: a case for the human microbiome in extra intestinal diseases. Gut Pathog. 2017;9:13.

3. Wendling D, Guillot X, Prati C, Miceli-Richard C, Molto A, Lories R, et al. Effect of gut involvement in patients with high probability of early spondyloarthritis: data from the DESIR cohort. J Rheumatol. 2020;47:349–53.

4. Horai R, Zárate-Bladés CR, Dillenburg-Pilla P, Chen J, Kielczewski JL, Silver PB, et al. Microbiota-dependent activation of an autoreactive T cell receptor provokes autoimmunity in an immunologically privileged site. Immunity. 2015;43:343–53.

5. McLean MH, Dieguez D Jr, Miller LM, Young HA. Does the microbiota play a role in the pathogenesis of autoimmune diseases? Gut. 2015;64:332–41.