The impact of tumour pH on cancer progression: strategies for clinical intervention-Reference-Cited by-同舟云学术

The impact of tumour pH on cancer progression: strategies for clinical intervention

Published:2020-04-09 Issue:2 Volume:1 Page:71-100
ISSN:
Container-title:Exploration of Targeted Anti-tumor Therapy
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Author:

Ward Carol¹,Meehan James¹,Gray Mark E²,Murray Alan F³,Argyle David J²,Kunkler Ian H¹,Langdon Simon P¹

Affiliation:

1. Cancer Research UK Edinburgh Centre and Edinburgh Pathology, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, EH4 2XU Edinburgh, UK

2. Royal (Dick) School of Veterinary Studies and Roslin Institute, University of Edinburgh, Easter Bush, EH25 9RG Midlothian, UK

3. School of Engineering, Institute for Integrated Micro and Nano Systems, EH9 3JL Edinburgh, UK

Abstract

Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms. Pathways associated with the control of intracellular pH that are under consideration for intervention include carbonic anhydrase IX, the monocarboxylate transporters (MCT, MCT1 and MCT4), the vacuolar-type H+-ATPase proton pump, and the sodium-hydrogen exchanger 1. This review will describe progress in the development of inhibitors to these targets.

Funder

Edinburgh and Lothians Health Foundation

Seventh Framework Programme

Engineering and Physical Sciences Research Council

Publisher

Open Exploration Publishing

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