Affiliation:
1. Affiliations:
Department of Biological Sciences, East Tennessee State University, TN 37614, USA
2. Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Abstract
Abstract
Artemisinin, a sesquiterpene lactone extracted from the sweet wormwood plant (
Artemisia annua
), is a crucial component in the production of artemisinin-based combination therapies (ACTs), the most effective treatment for malaria. In recent years, metabolic engineering has emerged as a powerful tool to enhance the production of artemisinin, both in microbial and plant chasses. This review article provides an overview of the recent literature on the metabolic engineering strategies employed to optimize artemisinin production, highlighting breakthroughs, challenges, and future directions.
Subject
Nature and Landscape Conservation,General Agricultural and Biological Sciences,General Veterinary