The radiosensitizing effects of L-Canavanine.
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Published:2008
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Volume:
Page:255-269
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ISSN:
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Container-title:Herbal radiomodulators: applications in medicine, homeland defence and space
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language:
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Author:
Worthen D. R.,Crooks P. A.
Abstract
AbstractL-Canavanine (L-2-amino-[4-guanidinooxy] butanoic acid, L-CAV) is a naturally occurring L-arginine (L-ARG) analogue produced by a variety of leguminous plants. The diverse biological activities and chemical structures of L-CAV and L-CAN are examined and a review of the radiosensitizing activity of L-CAV is presented. Promising targets for L-CAV-mediated radiosensitization (including histones and heat shock proteins) in cancer treatment are examined.