Peritumoral infiltration of local anesthetic before surgery in early breast cancer: a comment

Author:

Bessa Jordana de Faria1ORCID,Miranda Mila Meneguelli1ORCID,Bevilacqua José Luiz Barbosa1ORCID

Affiliation:

1. Rede D’Or, Breast Surgery, Brazil

Abstract

This is a comment on a study recently published about peritumoral infiltration of local anesthetic before surgery in early breast cancer. Previously, animal models and a randomized study for stage IV breast cancer patients inferred that the removal of the primary tumor resulted in increased growth factors and worse distant disease control. Therefore, breast cancer surgery might not be a strictly local intervention. In this new randomized study, the intervention was a peritumoral infiltration of local anesthetic — lidocaine 0.5% in the six tumor margins, as an attempt to limit the systemic repercussions of surgery. Although the adjuvant treatment available for the study seems outdated, leading us to question the external validation, limited resources may have increased the power of surgery. Unknown mechanisms during surgery can change the patient’s journey, and it is our duty to look at surgical studies with due seriousness.

Publisher

Mastology

Subject

Polymers and Plastics,General Environmental Science

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