Aetiological agents of adult community-acquired pneumonia in Japan: systematic review and meta-analysis of published data

Abstract

ObjectiveEpidemiological information is essential in providing appropriate empiric antimicrobial therapy for pneumonia. This study aimed to clarify the epidemiology of community-acquired pneumonia (CAP) by conducting a systematic review of published studies in Japan.DesignSystematic review.Data sourcePubMed and Ichushi web database (January 1970 to October 2022).Eligibility criteriaClinical studies describing pathogenic micro-organisms in CAP written in English or Japanese, excluding studies on pneumonia other than adult CAP, investigations limited to specific pathogens and case reports.Data extraction and synthesisPatient setting (inpatient vs outpatient), number of patients, concordance with the CAP guidelines, diagnostic criteria and methods for diagnosing pneumonia pathogens as well as the numbers of each isolate. A meta-analysis of various situations was performed to measure the frequency of each aetiological agent.ResultsFifty-six studies were included and 17 095 cases of CAP were identified. Pathogens were undetectable in 44.1% (95% CI 39.7% to 48.5%).Streptococcus pneumoniaewas the most common cause of CAP requiring hospitalisation or outpatient care (20.0% (95% CI 17.2% to 22.8%)), followed byHaemophilus influenzae(10.8% (95% CI 7.3% to 14.3%)) andMycoplasma pneumoniae(7.5% (95% CI 4.6% to 10.4%)). However, when limited to CAP requiring hospitalisation,Staphylococcus aureuswas the third most common at 4.9% (95% CI 3.9% to 5.8%).Pseudomonas aeruginosawas more frequent in hospitalised cases, while atypical pathogens were less common. Methicillin-resistantS. aureusaccounted for 40.7% (95% CI 29.0% to 52.4%) ofS. aureuscases. In studies that used PCR testing for pan-respiratory viral pathogens, human enterovirus/human rhinovirus (9.4% (95% CI 0% to 20.5%)) and several other respiratory pathogenic viruses were detected. The epidemiology varied depending on the methodology and situation.ConclusionThe epidemiology of CAP varies depending on the situation, such as in the hospital versus outpatient setting. Viruses are more frequently detected by exhaustive genetic searches, resulting in a significant variation in epidemiology.