Abstract
IntroductionEarly management of chronic respiratory diseases (CRDs) and frailty have been identified as key targets towards healthy ageing, but the association between CRDs and frailty has been poorly investigated. We studied the association between asthma and frailty in adults of the GAZEL cohort using different definitions of asthma over the 26 years of follow-up.MethodsCurrent asthma definitions are based on yearly self-reports of symptoms or medication (in 2015, constant reports or at least one report between 1990 and 2015), or on a detailed respiratory symptoms questionnaire in 2002. Frailty definition is based on weakness, fatigue, unintentional weight loss, low physical activity and mobility in 2015. Frail participants had three criteria or more, pre-frail 1 or 2, and robust 0. Multinomial regression models adjusted for age, sex, body mass index, smoking, education, marital status and comorbidities were performed.ResultsIn 2015, 12 345 adults (73% men, 61 to 77 years old) were included: 3% of them reported current asthma, 1.6% had constant reports during the follow-up and 9% reported current asthma at least once. In 2015, 6% were frail, 34% pre-frail and 13% of current asthmatics and 6% of non-asthmatics were frail (adjusted OR (aOR) 2.19 (1.44 to 3.34)). Significant associations were also found with the 2002 definition (aOR 2.24 (1.73 to 2.90)), constant reports (aOR 3.67 (1.70 to 7.93)) or at least once (aOR 1.50 (1.15 to 1.98)). Current asthma was also associated with pre-frailty with the 2002 definition (aOR 1.46 (1.26 to 1.68)).DiscussionParticipants with asthma had increased risk of frailty. A better understanding of their relationship could help to define and evaluate strategies for a better ageing of asthmatics.
Subject
Pulmonary and Respiratory Medicine
Reference33 articles.
1. United Nations D of E and SAPD (2017) . World population prospects: the 2017 revision, 2017. Available: https://esa.un.org/unpd/wpp/publications/files/wpp2017_volume-ii-demographic-profiles.pdf
2. Le vieillissement démographique sera plus rapide au Sud qu’au Nord;Pison;Popul Sociétés,2009
3. The European Innovation Partnership on Active and Healthy Ageing: The European geriatric medicine introduces the EIP on AHA column
4. Frailty: An Emerging Research and Clinical Paradigm--Issues and Controversies
5. Frailty: implications for clinical practice and public health;Hoogendijk;Lancet,2019
Cited by
16 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献