Role of interferon gamma release assay in the diagnosis and management of Mycobacterium tuberculosis-associated uveitis: a review

Author:

Rahman Samra,Irfan Muhammad,Siddiqui M A RehmanORCID

Abstract

Tuberculosis (TB)-associated uveitis is a common cause of infectious uveitis in the developing world. Diagnosis of TB uveitis remains a challenge. The role of interferon gamma release assays (IGRAs) is uncertain. Herein we summarise the available literature on the utility of IGRAs in the diagnosis and management of TB uveitis. We searched PubMed database from 1 August 2010 to 31 July 2020 using the following keywords alone and in combination: ‘interferon-gamma release assay’, ‘QuantiFERON’, ‘T-SPOT.TB’, ‘TB uveitis’, ‘serpiginous like choroiditis’, ‘tuberculoma’, ‘TB vasculitis’, ‘TB panuveitis’ and ‘ocular tuberculosis’. Data from 58 relevant studies were collated. The review is focused on currently marketed versions of IGRA tests: QuantiFERON-TB Gold In-Tube assay, QuantiFERON-TB Gold Plus assay (QFT-Plus) and T-SPOT.TB. We found limited evidence regarding the diagnostic utility of IGRA in patients with uveitis. No study was identified evaluating the newer QFT test—the QFT-Plus—in patients with uveitis. Similarly, there is lack of data directly comparing QFT-Plus with T-SPOT.TB specifically for the diagnosis of TB uveitis.

Publisher

BMJ

Subject

Ophthalmology

Reference67 articles.

1. Global tuberculosis report, 2019. Available: https://www.who.int/tb/publications/global_report/en/

2. Intraocular Tuberculosis

3. Ocular tuberculosis;Albert;Microbiol Spectr,2016

4. Ocular tuberculosis - A closer look to an increasing reality;Teixeira-Lopes;Pulmonology,2018

5. Ocular tuberculosis: position paper on diagnosis and treatment management;Figueira;Rev Port Pneumol,2017

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