1. APRIL 1989 of early signs such relapses could be attenuated to the point that their negative effects would be outweighed by the potential benefits of the new strategy. We expected our findings to accord with those found in so called "low dose" studies, in which reducing the dose of maintenance treatment to up to one tenth leads to an increase in the frequency of symptomatic exacerbations but no change in the frequency of serious relapse as evidenced by admission to hospital.9 120
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