1. The extracellular matrix composition of PVR periretinal membranes has also been analysed immunohistochemically16 1743 (Table 2). These studies have demonstrated the consistent presence of interstitial collagens types I and III and a variable presence of type II (vitreous associated) collagen. It had been postulated that both RPE and glial cells may be responsible for the elaboration ofthe collagens present.'7 The basal lamina proteins - type IV collagen, heparan sulphate, and laminin - have also been demonstrated,'6 17 notably where internal limiting membrane fragments are associated with the membrane specimen.'6 The cell attachment protein fibronectin has been identified as a significant component of PVR membranes.173443 Fibronectin mRNA labelling and protein immunostaining have been demonstrated on retinal glia, RPE, and fibroblastic cells in PVR epiretinal membranes44 suggesting an intrinsic production of fibronectin by PVR tissue
2. The effect of intraocular tamponade on the proliferative process is as yet uncertain. Studies on the use of silicone oil after vitrectomy in eyes with PVR have reported a high rate of retro-oil epiretinal membrane reproliferation,108 particularly;in association with large retinectomies.102 109
3. Rhegmatogenous retinal detachment without macular involvement treated with scleral buckling;Tani, P.; Robertson, D.M.; Langworthy, A.;Am J Ophthalmol,1980
4. Prognosis for central vision and anatomic reattachment in rhegmatogenous retinal detachment with macula detached;Tani, P.; Robertson, D.M.; Langworthy, A.;AmJ Ophthalmol,1981
5. Surgical treatment of superior bullous rhegmatogenous retinal detachments;Stanford, M.R.; Chignell, A.H.;BrJ Ophthalmol,1985