Abstract
Purpose
We examined the longitudinal association of baseline alcohol intake and
frequency with the 6-year incidence and progression of diabetic retinopathy
(DR) in a population-based cohort of Singaporean Indians.
Methods
We included 656 participants with diabetes mellitus, gradable retinal
photographs from baseline (2007–2009) and follow-up (2013–2015) examinations,
information on alcohol intake and other relevant data from the Singapore Indian
Eye Study were included. Incident DR was defined using the Modified Airlie
House Classification as no DR at baseline and at least minimal
non-proliferative DR at follow-up; and DR progression as at least a one-step
worsening in DR at follow-up from minimal or worse status at baseline,
excluding those with proliferative DR.
Results
The mean age (SD) of our participants (n=656) was 58.8 (9.2) years, and
54.4% were male. At follow-up, 82 of 510 (16%) participants developed DR, and
45 of 146 (30.8%) had DR progression. 65 (12.7%) and 28 (19.1%) participants
consumed alcohol in incident DR and progression categories, respectively. In
multivariable analyses, those who consumed alcohol had nearly two-thirds
reduced odds of incident DR (OR (95% CI): 0.36 (0.13 to 0.98)) compared with
those who did not. Participants with infrequent consumption of alcohol also had
a reduction in odds of incident DR (0.17 (0.04 to 0.69)), compared with
non-drinkers. No association was found between alcohol consumption and DR
progression.
Conclusions and relevance
In our longitudinal population of Singapore Indians, baseline alcohol
intake, particularly infrequent consumption, was associated with lower risk of
developing DR, compared with non-drinkers, in line with previous
cross-sectional findings.
Funder
National
Medical Research Council
Subject
Cellular and Molecular Neuroscience,Sensory Systems,Ophthalmology
Cited by
7 articles.
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