Abstract
Aims
To determine the association between albuminuria and primary open-angle
glaucoma (POAG).
Methods
Participants of the Singapore Chinese Eye study were recruited and
underwent standardised ocular and systemic examinations. Albuminuria was
determined using urinary albumin-to-creatinine ratio (UACR, mg/g) based on
random spot urinary albumin and creatinine measurements. POAG was defined using
the International Society of Geographic and Epidemiological Ophthalmology
classification. Multivariable logistic regression with generalised estimating
equation model was used to evaluate the association between albuminuria and
POAG, while accounting for correlation between eyes.
Results
A total of 3009 Chinese adults (5963 eyes), aged 40–80 years, were
included in this study, of which, 52 subjects (75 eyes) had POAG. Higher UACR
(per 50 mg/g increase) was independently associated with POAG (OR=1.04, 95% CI
1.01 to 1.07, p=0.003) following adjustment for age, gender, intraocular
pressure, diabetes mellitus, hyperlipidaemia, hypertension, anti-hypertensive
medication, history of cardiovascular disease, current smoking status, alcohol
intake, body mass index and estimated glomerular filtration rate. Further
stratification revealed that individuals with macroalbuminuria were 8.00 times
likely to have POAG (95% CI 2.97 to 21.54, p<0.001), compared with those
with normoalbuminuria. Microalbuminuria was not significantly associated with
POAG (OR=0.49, 95% CI 0.19 to 1.29, p=0.150). The association between
macroalbuminuria and POAG remained significant among individuals who were
diabetic (OR=9.89, 95% CI 2.49 to 39.30, p=0.001) and hypertensive (OR=8.39,
95% CI 3.07 to 22.94, p<0.001).
Conclusion
In this population-based study of Chinese adults, albuminuria was
independently associated with POAG. Our findings provide further understanding
on the pathogenesis of POAG and may potentially help to better identify
individuals at risk of POAG.
Subject
Cellular and Molecular Neuroscience,Sensory Systems,Ophthalmology
Cited by
4 articles.
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