Abstract
ObjectiveTo identify risk factors for haemorrhagic transformation in Chinese patients with acute ischaemic stroke treated with recombinant tissue plasminogen activator.MethodsWe searched electronic databases including PubMed, EMBASE, CNKI and WanFang Data for studies reporting risk factors of haemorrhagic transformation after intravenous thrombolysis. Pooled OR, weighted mean difference (WMD) and 95% CI were estimated. Meta-analysis was performed by using Stata V.14.0 software.ResultsA total of 14 studies were included. The results indicated that older age (WMD=3.46, 95% CI 2.26 to 4.66, I2=47), atrial fibrillation (OR 2.66, 95% CI 1.85 to 3.81, I2=28), previous stroke (OR 1.68, 95% CI 1.08 to 2.60, I2=14), previous antiplatelet treatment (OR 1.67, 95% CI 1.17 to 2.38, I2=0), higher National Institute of Health stroke scale scores (OR 1.10, 95% CI 1. 05 to 1.15, I2=36), systolic (WMD=4.75, 95% CI 2.50 to 7.00, I2=42) or diastolic (WMD=2.67, 95% CI 1.08 to 4.26, I2=35) pressure, and serum glucose level (WMD=1.44, 95% CI 0.62 to 2.26, I2=66) were associated with increased risk of post-thrombolysis haemorrhagic transformation.ConclusionThe current meta-analysis identified eight risk factors for post-thrombolysis haemorrhagic transformation in Chinese patients with acute ischaemic stroke. Given the risk of bias, these results should be explained with caution and do not justify withholding intravenous thrombolysis.
Funder
National Natural Science Foundation of China
Subject
Cardiology and Cardiovascular Medicine,Clinical Neurology
Cited by
18 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献