Structure and function of the insulin receptor—a personal perspective

Author:

KASUGA Masato1

Affiliation:

1. The Institute for Adult Disease, Asahi Life Foundation

Publisher

Japan Academy

Subject

General Physics and Astronomy,General Agricultural and Biological Sciences,General Medicine

Reference38 articles.

1. 1) Cuatrecasas, P. (1971) Insulin–receptor interactions in adipose tissue cells: Direct measurement and properties. Proc. Natl. Acad. Sci. U.S.A. 68, 1264–1268.

2. 2) Freychet, P., Roth, J. and Neville, D.M. Jr. (1971) Insulin receptors in the liver: Specific binding of (125I)insulin to the plasma membrane and its relation to insulin bioactivity. Proc. Natl. Acad. Sci. U.S.A. 68, 1833–1837.

3. 3) Kahn, C.R., Neville, D.M. Jr. and Roth, J. (1973) Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance. J. Biol. Chem. 248, 244–250.

4. 4) Flier, J.S., Kahn, C.R., Roth, J. and Bar, R.S. (1975) Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Science 190, 63–65.

5. 5) Kasuga, M., Akanuma, Y., Iwamoto, Y. and Kosaka, K. (1977) Effects of fasting and refeeding on insulin receptors and glucose metabolism in rat adipocytes. Endocrinology 100, 1384–1390.

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