Abstract
Objective. To improve intraoperative determination of «sentinel» lymph nodes in patients, suffering mammary gland cancer.
Materials and methods. In the 2016 – 2021 yrs period on the base of the Odessa Regional Clinical Hospital 200 patients, suffering mammary gland cancer Stages Т1–Т3N0М0, were operated, using two dyes: the blue patented dye and fluorescent dye indocyanine green. All the patients were distributed into two groups. In Group I in 100 patients the "sentinel" lymph nodes biopsy was conducted. The blue patented dye was used for the lymph nodes staining. The same was conducted in 100 patients of Group II with the "sentinel" lymph nodes biopsy. For the lymph nodes staining there were applied the blue patented dye and fluorescent dye indocyanine green, which were introduced intravenously into the upper extremity on the side of the affected mammary gland along outflow from the upper extremity to mammary gland.
Results. General five–year survival after axillary lympho–dissection and after biopsy of «sentinel» lymph nodes have constituted 91 and 92%, accordingly, while recurrence–free five–year survival – 82.2 and 83.9% accordingly. Only in 1.1% patient a regional recurrence in «sentinel» lymph nodes on the affected mammary gland side was revealed. In 57% patients the unaffected «sentinel» lymph nodes were diagnosed, that's why further lympho–dissection was accomplished. In 43% women–patients there was revealed metastatic affection of the lymph nodes. Recurrence was registered in 0.2% patients as an isolated metastases in axillary lymph nodes.
Conclusion. The method of the «sentinel» lymph nodes diagnosis in mammary gland cancer, using the dyes, permits to escape the performance of traumatic operations in favor of organ–preserving interventions with biopsy of «sentinel» lymph nodes.