Disease Mechanism and Treatment Method of Ebola Virus

Abstract

Ebola virus is a virus with simple structure, but it can assemble itself in the host and cause a chain reaction of washing in the process of disease causing, leading to more serious pathological damage in the body. Its main clinical characteristic is fever, bleeding, and diarrhea and has a high fatality rate, as well as endangering people's physical and mental health. Since Ebola virus was discovered in 1976, the virus has been in periodic outbreaks in Africa, and has also spread to countries and regions outside the African continent. The World Health Organization has twice listed Ebola as a public health emergency of international concern. In view of the huge challenges faced, the search for effective treatment methods and the research and development of preventive vaccines have become one of the problems that the medical community urgently needs to overcome. Antibody drugs also play an important role to prevent the spread of Ebola virus, improving patient protection rate and other aspects, making people see the hope of curing Ebola virus. So far, the American Food and Drug Administration (FDA) have approved REGN-EB3 and mAb114 as medicinal products for Ebola Virus therapy. This article reviews the risk factors, pathogenesis, clinical characteristics and treatment progress of Ebola virus, to provide a theoretical basis for the prevention and treatment of the virus.