Cancer Stem Cells and Their Drug Resistance Mechanisms

Abstract

Today, the prevalence rate of cancer continues to rise, and the mortality rate remains the first. In the face of tumor growth and deterioration, medical treatment methods are constantly updated, and drug resistance in the later stage of tumor is a thorny problem facing today. Cancer stem cells (CSCs) are an important factor leading to tumor drug resistance. The biological characteristics and drug resistance of tumor cells are important factors that determine tumor drug resistance. CSCs have unique biological characteristics, but they are similar to stem cells. It can self-proliferate and differentiate, have strong repair ability, can promote infinite growth of tumor, and have unique biological markers. The ABC protein drug pump function of CSCs can cope with the invasion of chemotherapy drugs. Its own microenvironment, strong inhibition of apoptosis and long-term stationary phase are the unique protective mechanism of CSCs. Aiming at the mechanism of cancer stem cells, the research on their properties is particularly important.