Author:
Huang Qingyu,Wang Fuhao,Hao Di,Li Xinyu,Li Xiaohui,Lei Tianyu,Yue Jinbo,Liu Chao
Abstract
AbstractDendritic cells (DCs) serve as a pivotal link connecting innate and adaptive immunity by processing tumor-derived antigens and activating T cells. The advent of single-cell sequencing has revolutionized the categorization of DCs, enabling a high-resolution characterization of the previously unrecognized diversity of DC populations infiltrating the intricate tumor microenvironment (TME). The application of single-cell sequencing technologies has effectively elucidated the heterogeneity of DCs present in the tumor milieu, yielding invaluable insights into their subpopulation structures and functional diversity. This review provides a comprehensive summary of the current state of knowledge regarding DC subtypes in the TME, drawing from single-cell studies conducted across various human tumors. We focused on the categorization, functions, and interactions of distinct DC subsets, emphasizing their crucial roles in orchestrating tumor-related immune responses. Additionally, we delve into the potential implications of these findings for the identification of predictive biomarkers and therapeutic targets. Enhanced insight into the intricate interplay between DCs and the TME promises to advance our comprehension of tumor immunity and, in turn, pave the way for the development of more efficacious cancer immunotherapies.
Funder
National Natural Science Foundation of China
Young TaiShan Scholars and Academic Promotion Program of Shandong First Medical University
Shandong Provincial Natural Science Foundation
Bethune Cancer Radiotherapy Translational Medicine Research Fund
Beijing Bethune Charitable Foundation
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Hematology
Cited by
1 articles.
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