Association between 14 candidate genes, PM2.5, and affective disorders: a study of the Taiwan Biobank
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Published:2023-11-27
Issue:1
Volume:23
Page:
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ISSN:1471-2458
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Container-title:BMC Public Health
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language:en
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Short-container-title:BMC Public Health
Author:
Ma Kai-Jie,Lin Yi-Ju,Liu Chiu-Shong,Tseng Pei-Ying,Wang Shi-Heng,Yao Chi-Yu,Wang Jong-Yi
Abstract
Abstract
Background
Most studies have focused on the risk factors, treatment, and care of affective psychosis, and several have reported a relationship between ambient air quality and this psychosis. Although an association has been reported between psychosis and genes, studies mainly explored the associations between one type of psychosis and one gene; few have identified genes related to affective psychosis. This study investigates the genetic and environmental factors of affective psychosis.
Methods
In this retrospective longitudinal study, 27 604 participants aged 30–70 were selected from Taiwan Biobank. The participants’ propensity scores were calculated based on their demographic information, and propensity score matching was performed to divide the participants into an experimental (i.e., affective psychosis) and control group at a 1:5 ratio. Plink was used to analyze the major and minor types of gene expression related to affective psychosis, and PM2.5 exposure was incorporated into the analyses.
Results
According to the generalized estimating equation analysis results, 8 single nucleotide polymorphisms (SNPs) belonging to the ANK3, BDNF, CACNA1C, and GRID1 genotypes were significantly correlated with depressive disorder (P < .001), with the majority belonging to the ANK3 and CACNA1C. A total of 5 SNPs belonging to the CACNA1C, GRID1, and SIRT1 genotypes were significantly correlated with bipolar disorder (P < .001), with the majority belonging to the CACNA1C. No significant correlation was identified between ambient air pollution and affective psychosis.
Conclusions
CACNA1C and GRID1 are common SNP genotypes for depressive disorder and bipolar disorder and should be considered associated with affective psychosis.
Funder
Ministry of Science and Technology, Taiwan
China Medical University, Taiwan
Tainan Municipal An-Nan Hospital
Publisher
Springer Science and Business Media LLC
Subject
Public Health, Environmental and Occupational Health
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