Author:
Ren Qingwei,Chen Yanyan,Shao Xuejun,Guo Lanzhong,Xu Xinxin
Abstract
Abstract
Objective
To assess the diagnostic efficacy of 18F-FDG PET/MRI for lymph node (LN) metastasis primary staging in patients with colorectal cancer (CRC).
Methods
This study was conducted and reported in accordance with the PRISMA-DTA statement. Electronic databases (PubMed, Embase, Cochrane Library) were searched for studies on 18F-FDG PET/MRI for diagnosing LN metastasis. The pooled sensitivity (SEN), specificity (SPE), and area under the curve (AUC) were applied to assess the diagnostic performance. Heterogeneity was identified and processed using meta-regression and sensitivity analysis. All data analyses were performed via STATA 15 and Meta-Disc 1.4 software.
Results
There were finally 7 studies included, involving a total of 184 patients. The Spearman rank correlation coefficient was 0.108 (P = 0.818), with no threshold-effect observed. The pooled SEN was 0.81 (95%CI 0.66–0.90) and the SPE was 0.89 (95% CI 0.73–0.96). In sub-groups, prospective groups demonstrated to have the highest SEN of 0.92 (95%CI 0.79–1.00). The studies conducted by Catalano et al. and Kang et al. were considered to be potential sources of heterogeneity.
Conclusion
18F-FDG PET/MRI has shown remarkable diagnostic performance in identification of LN metastases in newly diagnosed CRC patients. It would be of great application value for the primary staging of CRC lymph node metastases.
Funder
Zhejiang Famous Traditional Chinese Medicine Expert Inheritance Studio Construction Project Guo Lanzhong Famous Traditional Chinese Medicine Expert Inheritance Studio
Publisher
Springer Science and Business Media LLC
Reference34 articles.
1. Siegel RL, Miller KD, Goding Sauer A, Fedewa SA, Butterly LF, Anderson JC, Cercek A, Smith RA, Jemal A. Colorectal cancer statistics, 2020. CA Cancer J Clin. 2020;70(3):145–64.
2. Keum N, Giovannucci E. Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies. Nat Rev Gastroenterol Hepatol. 2019;16(12):713–32.
3. Wiltink LM, White K, King MT, Rutherford C. Systematic review of clinical practice guidelines for colorectal and anal cancer: the extent of recommendations for managing long-term symptoms and functional impairments. Support Care Cancer. 2020;28(6):2523–32.
4. Zhou L, Wang JZ, Wang JT, Wu YJ, Chen H, Wang WB, Cao F, Cheng GX. Correlation analysis of MR/CT on colorectal cancer lymph node metastasis characteristics and prognosis. Eur Rev Med Pharmacol Sci. 2017;21(6):1219–25.
5. Hadjipetrou A, Anyfantakis D, Galanakis CG, Kastanakis M, Kastanakis S. Colorectal cancer, screening and primary care: a mini literature review. World J Gastroenterol. 2017;23(33):6049–58.