Glucose metabolism-related gene polymorphisms as the risk predictors of type 2 diabetes-Reference-Cited by-同舟云学术

Glucose metabolism-related gene polymorphisms as the risk predictors of type 2 diabetes

Published:2020-11-04 Issue:1 Volume:12 Page:
ISSN:1758-5996
Container-title:Diabetology & Metabolic Syndrome
language:en
Short-container-title:Diabetol Metab Syndr

Author:

Li Cuilin^ORCID,Yang Yuping,Liu Xin,Li Zhongyu,Liu Hong,Tan Qiuhong

Abstract

AbstractType 2 diabetes mellitus (T2DM) is a complex polygenic metabolic disease characterized by elevated blood glucose. Multiple environmental and genetic factors can increase the risk of T2DM and its complications, and genetic polymorphisms are no exception. This review is mainly focused on the related genes involved in glucose metabolic, including G6PC2, GCK, GCKR and OCT3. In this review, we have summarized the results reported globally and found that the genetic variants of GCK and OCT3 genes is a risk factor for T2DM while G6PC2 and GCKR genes are controversial in different ethnic groups. Hopefully, this summary could possibly help researchers and physicians understand the mechanism of T2DM so as to diagnose and even prevent T2DM at early time.

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

http://link.springer.com/content/pdf/10.1186/s13098-020-00604-5.pdf

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