Author:
Boros Gustavo André Boeing,Hueb Whady,Rezende Paulo Cury,Rochitte Carlos Eduardo,Nomura Cesar Higa,Lima Eduardo Gomes,de Oliveira Laterza Ribeiro Matheus,Dallazen Anderson Roberto,Garcia Rosa Maria Rahmi,Ramires Jose Antonio Franchini,Kalil-Filho Roberto
Abstract
Abstract
Background
This study investigates myocardial structural changes in stable coronary artery disease (CAD) patients with type 2 diabetes (T2D) using cardiac magnetic resonance (CMR) strain and T1 mapping.
Methods
A total of 155 stable CAD patients underwent CMR examination, including left ventricular (LV) morphology and function assessment, late gadolinium enhancement (LGE), and feature tracking (CMR-FT) for LV global longitudinal, circumferential, and radial strain. T1 mapping with extracellular volume (ECV) evaluation was also performed.
Results
Among the enrolled patients, 67 had T2D. Diabetic patients exhibited impaired LV strain and higher ECV compared to non-diabetics. Multivariate analysis identified T2D as an independent predictor of increased ECV and decreased strain.
Conclusions
CMR-based strain and T1 mapping highlighted impaired myocardial contractility, elevated ECV, and potential interstitial fibrosis in diabetic patients with stable CAD. This suggests a significant impact of diabetes on myocardial health beyond CAD, emphasizing the importance of a comprehensive assessment in these individuals.
Trial registration
http://www.controlled-trials.com/ISRCTN09454308
Funder
Zerbini Foundation
Fundação de Amparo á Pesquisa do Estado de São Paulo
Publisher
Springer Science and Business Media LLC
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