The value of serum neutralizing antibody in evaluating predictability of COVID-19 after recovery and the validation of vaccine-Reference-Cited by-同舟云学术

The value of serum neutralizing antibody in evaluating predictability of COVID-19 after recovery and the validation of vaccine

Published:2023-12-20 Issue:1 Volume:23 Page:
ISSN:1471-2334
Container-title:BMC Infectious Diseases
language:en
Short-container-title:BMC Infect Dis

Author:

Guo Bianqin,Li Zheng,Fu Gang,Li Hong,Yang Jing,Zhang Zhenbin,Wu Lixiang,Wang Jing

Abstract

Abstract Background This work aimed to study natural humoral immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods Chemiluminescent immunoassay (CLIA) was used to detect the neutralizing antibody (Nabs) and IgG. Results Nabs peaked on days 57–96 after symptom onset and remained detected on days 97–132. The Nabs in the 32 patients who were dynamically monitored showed four changing patterns. The titers of Nabs and IgG were correlated, and three modes of relationship were found between them. Conclusions Nabs showed a regular change in the course of coronavirus disease 2019 (COVID-19). The detection of Nabs is very important for monitoring the course of COVID-19 and predicting the strength of antibody protection.

Funder

the Coronavirus Disease 2019 Emergency Scientific Research Project of Chongqing University

Chongqing Natural Science Foundation Project

the medical scientific research project of Chongqing Health Commission

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases

Link

https://link.springer.com/content/pdf/10.1186/s12879-023-08465-9.pdf

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