An imported malaria case with repeated episodes of neurological syndromes resulting from different Plasmodium species

Author:

Xiang Zheng,Zhou Longcan,Pan Maohua,Qin Yucheng,Bai Yao,Qin Pien,Zeng Weilin,Wei Xiaosheng,Lu Yuxin,Somboonwit Charurut,Menezes Lynette,Huang Yaming,Cui Liwang,Yang Zhaoqing

Abstract

Abstract Background Imported cerebral malaria (CM) cases in non-endemic areas are often misdiagnosed, which delays treatment. Post-malaria neurological syndrome (PMNS) after recovery from severe malaria can also complicate diagnosis. Case We report an imported malaria case from West Africa with two sequential episodes with neurological syndromes within about a month. The first episode was diagnosed as CM with microscopy-positive Plasmodium falciparum infection. The second episode, occurring a month after the recovery from the first CM episode, was consistent with PMNS, since malaria parasites were not detected by microscopy in peripheral blood smears. However, this diagnosis was complicated by the detection of Plasmodium vivax in peripheral blood by PCR, suggesting a potential cause of the second episode by P. vivax. Conclusion This study suggests that PMNS often occurs after severe falciparum malaria. Concurrent P. vivax infection with pathogenic biomass being predominantly extravascular further complicates accurate diagnosis.

Funder

Yunnan Applied Basic Research Projects-Union Foundation

International Science and Technology Cooperation-Yunnan International Science and Technology Cooperation Base

National Institutes of Health, USA.

National Science Foundation of China

Major science and technology projects of Yunnan Province

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases

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