Prevalence and risk factors of tuberculosis among people living with HIV/AIDS in China: a systematic review and meta-analysis
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Published:2023-09-06
Issue:1
Volume:23
Page:
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ISSN:1471-2334
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Container-title:BMC Infectious Diseases
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language:en
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Short-container-title:BMC Infect Dis
Author:
Qi Cong-Cong,Xu Li-Ran,Zhao Chang-Jia,Zhang Hai-Yan,Li Qing-Ya,Liu Mei-Jun,Zhang Ye-Xuan,Tang Zhou,Ma Xiu-Xia
Abstract
Abstract
Objective
To estimate the prevalence and risk factors associated with tuberculosis (TB) among people living with human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS) in China.
Methods
A systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. After the literature was screened based on the inclusion and exclusion criteria, STATA® version 17.0 software was used for the meta-analysis. The heterogeneity among study data was assessed using I2 statistics. Subgroup analysis and meta-regressions were performed to further explore the source of heterogeneity.
Results
A total of 5241 studies were retrieved. Of these, 44 studies were found to be eligible. The pooled prevalence of HIV/TB co-infection was 6.0%. The risk factors for HIV/TB co-infection included a low CD4+ T cell count, smoking, intravenous drug use and several other sociodemographic and clinical factors. Bacillus Calmette–Guérin (BCG) vaccination history was a protective factor.
Conclusion
A high prevalence of TB was observed among people living with HIV/AIDS in China. Low CD4+ T cell count, smoking, and intravenous drug use were the primary risk factors for HIV/TB co-infection, whereas BCG vaccination history was a protective factor. Checking for TB should be prioritized in HIV screening and healthcare access.
Systematic review registration
Registered on PROSPERO, Identifier: CRD42022297754.
Funder
Project of National Administration of Traditional Chinese Medicine
Special Project for Research on Traditional Chinese Medicine in Henan Province
Natural Science Foundation of Henan Province
Science and Technology Research Project of Henan Province
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases
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