Author:
Rezaie Jafar,Jahanghiri Mojtaba,Heris Reza Mosaddeghi-,Hassannezhad Sina,Abdyazdani Nima,Rahbarghazi Afshin,Ahmadi Mahdi
Abstract
Abstract
Background
In recent years, the role of autophagy has been highlighted in the pathogenesis of diabetes and inflammatory lung diseases. In this study, using a diabetic model of mice, we investigated the expression of autophagy-related genes in the lung tissues following melatonin administration.
Results
Data showed histopathological remodeling in lung tissues of the D group coincided with an elevated level of IL-6, Becline-1, LC3, and P62 compared to the control group (p < 0.05). After melatonin treatment, histopathological remodeling was improved D + Mel group. In addition, expression levels of IL-6, Becline-1, LC3, and P62 were decreased in D + Mel compared to D group (P < 0.05). Statistically significant differences were not obtained between Mel group and C group (p > 0.05).
Conclusion
Our results showed that melatonin injection can be effective in the amelioration of lung injury in diabetic mice presumably by modulating autophagy-related genes.
Publisher
Springer Science and Business Media LLC
Reference42 articles.
1. Atkinson MA, Eisenbarth GS, Michels AW. Type 1 diabetes. Lancet. 2014;383:69–82.
2. Hacioglu C, Kar F, Kara Y, Yucel E, Donmez DB, Sentürk H, Kanbak G. Comparative effects of metformin and Cistus laurifolius L. extract in streptozotocin-induced diabetic rat model: oxidative, inflammatory, apoptotic, and histopathological analyzes. Environ Sci Pollut Res. 2021;28:57888–901.
3. Daryabor G, Atashzar MR, Kabelitz D, Meri S, Kalantar K. The effects of type 2 diabetes mellitus on organ metabolism and the immune system. Front Immunol. 2020;11:1582.
4. Zarafshan E, Rahbarghazi R, Rezaie J, Aslani MR, Saberianpour S, Ahmadi M, Keyhanmanesh R. Type 2 diabetes mellitus provokes rat immune cells recruitment into the pulmonary niche by up-regulation of endothelial adhesion molecules. Advanced Pharmaceutical Bulletin. 2022;12:176.
5. Samarghandian S, Afshari R, Sadati A. Evaluation of lung and bronchoalveolar lavage fluid oxidative stress indices for assessing the preventing effects of safranal on respiratory distress in diabetic rats. Scientific World Journal. 2014;2014:251378.