Author:
Zhong Musen,Fan Guangya,An Zhongcheng,Chen Chen,Dong Liqiang
Abstract
AbstractSpinal cord injury is a complex central nervous system disease with an unsatisfactory prognosis, often accompanied by multiple pathological processes. However, the underlying mechanisms of action of this disease are unclear, and there are no suitable targeted therapeutic options. Long non-coding RNA mediates a variety of neurological diseases and regulates various biological processes, including apoptosis and autophagy, inflammatory response, microenvironment, and oxidative stress. It is known that long non-coding RNAs have significant differences in gene expression in spinal cord injury. To further understand the mechanism of long non-coding RNA action in spinal cord injury and develop preventive and therapeutic strategies regarding spinal cord injury, this review outlines the current status of research between long non-coding RNAs and spinal cord injury and potential long non-coding RNAs targeting spinal cord injury.
Funder
Zhejiang Provincial TCM Science and Technology Plan Project
Special Project of Modernization of Traditional Chinese Medicine in Zhejiang Province
National TCM Clinical Research Base Support Discipline Construction Plan
Publisher
Springer Science and Business Media LLC
Subject
Orthopedics and Sports Medicine,Surgery