Author:
Li Dongze,Liu Yi,Jia Yu,Yu Jing,Li Fanghui,Li Hong,Ye Lei,Liao Xiaoyang,Wan Zhi,Zeng Zhi,Cao Yu
Abstract
Abstract
Background
Malnutrition is associated with a high risk of mortality in adults with ischemic stroke (IS). This study aimed to investigate the relationship between malnutrition and the risk of stroke-associated pneumonia (SAP) as only a few studies examined the relationship between malnutrition and the risk of SAP in IS.
Methods
Patients were included from emergency departments of five tertiary hospitals in the REtrospective Multicenter study for Ischemic Stroke Evaluation (REMISE) study from January 2020 to December 2020. Malnutrition was defined according to the Controlling Nutritional Status (CONUT), Geriatric Nutritional Risk Index (GNRI), and Prognostic Nutritional Index (PNI) systems. Multivariable logistic regression analysis was used to explore the association between malnutrition and risk of SAP.
Results
We enrolled 915 patients with IS, 193 (14.75%), 495 (54.1%), and 148 (16.2%) of whom were malnourished according to the PNI, CONUT, and GNRI scores, respectively. SAP occurred in 294 (32.1%) patients. After adjusting for confounding influencing factors in the logistic regression analysis, malnutrition (moderate and severe risk vs. absent malnutrition) was independently associated with an increased risk of SAP based on the PNI (odds ratio [OR], 5.038; 95% confidence interval [CI] 2.435–10.421, P < 0.001), CONUT (OR, 6.941; 95% CI 3.034–15.878, P < 0.001), and GNRI (OR, 2.007; 95% CI 1.186–3.119, P = 0.005) scores. Furthermore, adding malnutrition assessment indices to the A2DS2 score significantly improved the ability to predict SAP by analysis of receiver operating characteristic curves and net reclassification improvement.
Conclusion
Malnutrition was notably prevalent in patients with IS and independently associated with an increased risk of SAP. Further studies are required to identify the effect of interventions on malnutrition to reduce the risk of SAP.
Funder
Health and Family Planning Commission of Sichuan Province
Sichuan Province Science and Technology Support Program
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),General Medicine
Cited by
3 articles.
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