Abstract
AbstractHypothermia has been observed during hypergravity load in mice and rats. This response is beneficial for maintaining blood glucose level, although food intake decreases. However, saving glucose is not enough to maintain blood glucose level during hypergravity load. In this study, we examined the contribution of humoral factors related to glycolysis in maintaining blood glucose level in a 2 G environment. Increased plasma corticosterone levels were observed in mice with intact peripheral vestibular organs, but not in mice with vestibular lesions. Plasma glucagon levels did not change, and decrease in plasma adrenaline levels was observed in mice with intact peripheral vestibular organs. Accordingly, it is possible that increase in plasma corticosterone level and hypothermia contribute to prevent hypoglycemia in a 2 G environment.
Funder
Japan Society for the Promotion of Science
Takeda Science Foundation
Suzuken Memorial Foundation
Takahashi Industrial and Economic Research Foundation
Japan Aerospace Exploration Agency
Gifu University
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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