Author:
Shu Yuanlu,Deng Ziwei,Deng Ye,Zhou Jianliang,Wang Jin,Duan Zhenxing,Jiang Tao,Zhao Xiang,Shi Zhihua,Qiu Chengfeng
Abstract
Abstract
Objectives
Pro-protein convertase subtilisin/kexin 9 (PCSK9) decreases the clearance of the pathogenic lipids, supporting the potential role of PCSK9 in the prognosis of sepsis.
Methods
In this prospective cohort study, patients with sepsis were consecutively recruited from 1 to 2020 to 30 September 2021 at the First People’s Hospital of Huaihua, China. All the eligible patients were categorized into low-PCSK9 and high-PCSK9 groups, based on their PCSK9 levels at admission. Time-dependent receiver operating characteristic curves and Cox proportional hazards regression were used to evaluate the association between PCSK9 level and 28-day mortality of sepsis.
Results
Of the 203 enrolled patients, 56 (27.59%) died during the 28-day follow-up. The PCSK9 level was positively related to the C-reactive protein level. The cut-off point of PCSK9 levels for 28-day mortality risk was 370 ng/ml. Through comparison between high-PCSK9 (> 370 ng/ml) with low-PCSK9 (≤ 370 ng/ml) groups, the adjusted HR for mortality was 2.56 (95% CI: 1.25–5.23, p = 0.01).
Conclusions
The 28-day mortality of sepsis increased significantly as the baseline circulating PCSK9 level exceeded 370 ng/ml, indicating circulating PCSK9 levels may be a potential biomarker to predict the prognosis of sepsis.
Funder
School-level Scientific Research Project of Jishou University, CN
Health Commission Program of Hunan province, CN
Science and Technology Plan Project of the Huaihua city, CN
Natural Science Foundation of Hunan Province, CN
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC