Modulation of GABA by sodium butyrate ameliorates hypothalamic inflammation in experimental model of PCOS

Author:

Eepho Oony-Iye,Bashir Al-Amin M.,Oniyide Adesola A.,Aturamu Ayodeji,Owolabi Olutunmise V.,Ajadi Isaac O.,Fafure Adedamola A.,Ajadi Mary B.,Areloegbe Stephanie E.,Olaniyi Kehinde S.ORCID

Abstract

AbstractPolycystic ovarian syndrome (PCOS) is a known endocrine disorder that has affected many women of childbearing age, and is accompanied by various neurodegenerative conditions. Hence, this study investigates the impact of butyrate in reversing hypothalamic-related disorder, possibly through γ aminobutyric acid (GABA) in a rat model of PCOS. Eight-week-old female Wistar rats were allotted into four groups (n = 5), which include control, butyrate, letrozole, and letrozole + butyrate groups. PCOS was induced by administering 1 mg/kg of letrozole (oral gavage) for 21 days. After confirmation of PCOS, 200 mg/kg of butyrate (oral gavage) was administered for 6 weeks. Rats with PCOS were characterized by elevated levels of plasma insulin and testosterone. Increases in plasma and hypothalamic triglyceride levels, inflammatory biomarker (SDF-1), apoptotic marker (caspase-6), and decreased plasma GnRH were observed. Additionally, a decrease in hypothalamic GABA was revealed. Nevertheless, the administration of butyrate attenuated these alterations. The present study suggests that butyrate ameliorates hypothalamic inflammation in an experimental model of PCOS, a beneficial effect that is accompanied by enhanced GABA production.

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,General Neuroscience

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